Product Description
Nicotine Benzoate is a pharmaceutical-grade nicotine salt formed by the reaction of nicotine with benzoic acid. It is widely used in pharmaceutical applications, nicotine replacement therapies, and e-liquids for vaping products. Nicotine Benzoate offers better stability, solubility, and bioavailability compared to freebase nicotine, making it an ideal choice for various formulations.
At Prism Industries Pvt. Ltd., we manufacture high-purity Nicotine Benzoate, ensuring compliance with global regulatory standards. Our Nicotine Benzoate is meticulously tested for purity, potency, and quality, making it a preferred ingredient in the pharmaceutical and nicotine industries.
Identification
- Chemical Name: Nicotine Benzoate
- Molecular Formula: C10H14N2·C7H6O2
- Molecular Weight: 274.3 g/mol
- CAS Number: [Specific CAS number]
- Synonyms: Nicotine Benzoate Salt, Nicotine Benzoic Acid Salt
- Appearance: White to off-white crystalline powder
- Odor: Mild nicotine-like odor
Nicotine Benzoate is a stable salt form of nicotine that enhances nicotine absorption, reduces harshness, and provides a smoother experience in formulations.
Regulatory Documents & Compliance
Nicotine Benzoate produced by Prism Industries Pvt. Ltd. complies with stringent global regulatory guidelines. We provide the following documents to ensure quality and compliance:
- Certificate of Analysis (COA) – Confirms product purity, potency, and compliance with specifications.
- Material Safety Data Sheet (MSDS) – Outlines safety, handling, and storage precautions.
- Good Manufacturing Practices (GMP) Certificate – Ensures production in a controlled and quality-certified environment.
- USP/NF Compliance – Meets pharmacopeial standards for pharmaceutical applications.
- TSE/BSE Statement – Certifies the absence of transmissible spongiform encephalopathies.
- Non-GMO Statement – Confirms that Nicotine Benzoate is free from genetically modified organisms.
- Stability Data – Provides information on product stability under different storage conditions.
At Prism Industries Pvt. Ltd., we prioritize regulatory compliance, ensuring that Nicotine Benzoate meets industry standards and customer requirements.
Specifications of Nicotine Benzoate
Our Nicotine Benzoate undergoes rigorous quality control testing to meet the following specifications:
Parameter | Specification |
Appearance | White to off-white crystalline powder |
Odor | Characteristic mild nicotine-like odor |
Assay (Purity by HPLC) | ≥ 99.0% |
Melting Point | 85-100°C |
Loss on Drying | ≤ 1.0% |
Heavy Metals | ≤ 10 ppm |
Solubility | Soluble in water, ethanol, and propylene glycol |
pH (5% Solution in Water) | 5.5 – 7.5 |
Residual Solvents | Complies with ICH Q3C guidelines |
These stringent specifications ensure Nicotine Benzoate is of the highest quality, suitable for use in pharmaceuticals, nicotine replacement therapy (NRT) products, and other applications.
Solubility of Nicotine Benzoate
The solubility of Nicotine Benzoate plays a crucial role in its pharmaceutical and vaping applications.
- Water Solubility: Highly soluble in water, enhancing its absorption in formulations.
- Ethanol Solubility: Completely soluble, making it suitable for liquid formulations.
- Propylene Glycol Solubility: Compatible with common solvent systems in nicotine formulations.
- Glycerin Solubility: Partially soluble; requires mixing for homogeneity in formulations.
The superior solubility profile of Nicotine Benzoate ensures its effectiveness in various nicotine-based applications.
Assay of Nicotine Benzoate
The assay of Nicotine Benzoate is determined using High-Performance Liquid Chromatography (HPLC) to ensure product purity and potency.
HPLC Assay Method for Nicotine Benzoate
- Instrument: High-Performance Liquid Chromatography (HPLC)
- Mobile Phase: Acetonitrile: Water (60:40) with 0.1% phosphoric acid
- Column: C18 (250 mm × 4.6 mm, 5 µm)
- Detection Wavelength: 254 nm
- Flow Rate: 1.0 mL/min
- Injection Volume: 10 µL
- Retention Time: 5.2 ± 0.3 minutes
- Assay Specification: ≥ 99.0% purity
Our Nicotine Benzoate consistently meets or exceeds 99.0% purity, ensuring its suitability for pharmaceutical-grade applications.
Chromatographic Purity by HPLC
The chromatographic purity of Nicotine Benzoate is a critical quality parameter that identifies and quantifies impurities present in the product.
HPLC Conditions for Chromatographic Purity Analysis
- Mobile Phase: Acetonitrile: Phosphate Buffer (70:30)
- Column: C18 (150 mm × 4.6 mm, 5 µm)
- Flow Rate: 1.2 mL/min
- Detection Wavelength: 260 nm
- Retention Time: 5.0 ± 0.3 minutes
- Total Impurities Limit: ≤ 0.5%
Our Nicotine Benzoate undergoes advanced HPLC testing to detect any residual impurities, ensuring pharmaceutical-grade purity and quality.
Key Applications of Nicotine Benzoate
- Nicotine Replacement Therapies (NRTs): Used in gums, patches, lozenges, and inhalers to aid smoking cessation.
- Pharmaceutical Formulations: Provides a controlled release of nicotine in medications.
- E-Liquids and Vaping Products: Offers smoother nicotine delivery with enhanced absorption.
Tobacco-Free Nicotine Alternatives: Used in nicotine pouches and oral products.
Why Choose Prism Industries Pvt. Ltd. for Nicotine Benzoate?
As a leading manufacturer of Nicotine Benzoate, Prism Industries Pvt. Ltd. offers:
✔ High Purity: Assay of ≥ 99.0%, ensuring premium quality.
✔ Regulatory Compliance: Meets USP, GMP, and ICH standards.
✔ Advanced Quality Control: Rigorous testing with HPLC and GC methods.
✔ Global Supply Capability: Reliable distribution for international markets.
✔ Sustainable Production: Eco-friendly manufacturing processes.
Nicotine Benzoate is an essential nicotine salt used in pharmaceuticals, smoking cessation products, and e-liquids. Its high purity, superior solubility, and compliance with international quality standards make it a preferred choice for various applications.
At Prism Industries Pvt. Ltd., we specialize in producing pharmaceutical-grade Nicotine Benzoate, ensuring premium quality and regulatory compliance. Whether you need Nicotine Benzoate for APIs, nicotine replacement therapy (NRT), or e-liquid formulations, we are your trusted supplier.
For high-quality Nicotine Benzoate, contact us today to discuss your requirements and bulk supply needs.
New headquarters, new possibilities
Gain insight into the manufacturing processes of Chemnovatic NicSalts, PureNic 99+, and other nicotine products, as well as our headquarters and production plant located in Poland, by checking out the video below. This will help you understand how and where these products are made
Related Products
Our minimum order quantities vary depending on the product:
- Active Pharmaceutical Ingredients (APIs): 1 kg
- Excipients: 5 kg
- Finished Dosage Forms: 1,000 units
- Custom Orders: Determined on a case-by-case basis
We accept the following payment methods:
- Bank Transfers: EUR, USD, GBP
- Credit/Debit Cards: Visa, MasterCard
- PayPal: For international transactions
API Pharmaceutical Manufacturing Company is a dedicated manufacturer of high-quality pharmaceutical ingredients and finished products. We control the entire production process to ensure compliance with the highest standards of quality and safety.
We primarily serve business clients in the pharmaceutical, biotech, and healthcare industries. For individual customers, we recommend reaching out to our authorized distributors.